HOXA11 Antibody

Homeobox protein A11 is a protein that in humans is encoded by the HOXA11 gene. It is mapped to 7p15.2. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is involved in the regulation of uterine development and is required for female fertility. HOXA11 is essential for the development of the uterosacral ligaments, it has been found that women with pelvic organ prolapse may have weakened connective tissue due to changes in this signaling pathway. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.