Rad17 Polyclonal Antibody

RAD17 checkpoint clamp loader component encoded by RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. RAD17 checkpoint clamp loader component shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. RAD17 checkpoint clamp loader component binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. RAD17 checkpoint clamp loader component recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of RAD17 checkpoint clamp loader component is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of RAD17, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

The Rad17 Polyclonal Antibody is a highly reliable and efficient tool designed for the detection and analysis of Rad17 protein expression in various biological samples. This antibody is produced using advanced techniques, ensuring its high specificity and sensitivity.

The Rad17 protein plays a crucial role in the DNA damage response pathway, specifically in the activation of cell cycle checkpoints and DNA repair mechanisms. By targeting Rad17, this polyclonal antibody enables researchers to investigate the intricate mechanisms underlying DNA damage and repair processes.

With its exceptional performance, this antibody exhibits minimal cross-reactivity with other proteins, ensuring accurate and precise results. It is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Rad17 Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy integration into various experimental protocols. Its high affinity and specificity make it an ideal choice for both basic research and clinical studies.

In summary, the Rad17 Polyclonal Antibody is a valuable tool for scientists and researchers seeking to explore the intricate pathways involved in DNA damage response. Its exceptional performance, reliability, and versatility make it an indispensable asset in the field of molecular biology and beyond.