RAGE Polyclonal Antibody

The advanced glycosylation end product (AGE) receptor encoded by AGER is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID: 18089847).

The RAGE Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Receptor for Advanced Glycation Endproducts (RAGE) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human RAGE protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The RAGE Polyclonal Antibody is a valuable tool for researchers studying the role of RAGE in various physiological and pathological processes, including inflammation, diabetes, cancer, and neurodegenerative diseases. This antibody has been shown to detect RAGE in a variety of species, including human, mouse, rat, and bovine, making it a versatile reagent for cross-species studies.

The RAGE Polyclonal Antibody is provided as a lyophilized powder and should be reconstituted in distilled water or PBS before use. The recommended working dilution for this antibody is 1:1000 for Western blotting and 1:200 for immunohistochemistry and immunofluorescence. This antibody has been tested and validated for its specificity and sensitivity, ensuring reliable and reproducible results in various applications.

In summary, the RAGE Polyclonal Antibody is a high-quality antibody that offers exceptional specificity and sensitivity for the detection of RAGE in various biological samples. This antibody is a valuable tool for researchers studying the role of RAGE in various physiological and pathological processes and is suitable for use in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence.