SLFN11 Antibody / Schlafen family member 11

Schlafen family member 11 is a protein that in humans is encoded by the SLFN11 gene. SLFN11 is a nuclear protein that belongs to the Schlafen (SLFN) family of genes involved in cell cycle regulation and growth inhibition. Expression of SLFN11 predicts sensitivity of cancer cell lines to DNA-damaging agents. Evidence suggests that in the presence of DNA-targeted therapies, SLFN11 is recruited to stressed replication forks where it blocks replication leading to cell death. SLFN11 is being explored as a predictive biomarker for response to DNA-targeted therapies.