PDS5B Antibody / AS3

Sister chromatid cohesion protein PDS5 homolog B (PDS5B), also called Androgen-induced prostate proliferative shutoff-associated protein AS3, or simply 'AS3,' is a protein that in humans is encoded by the PDS5B gene. This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene.