ATF4 Antibody

ATF4, Activating Transcription Factor 4, is also known as Cyclic AMP-responsive element-binding protein 2 (CREB-2). ATF4/CREB-2 belongs to the large ATF/CREB family of transcription factors which bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. Unlike CREB, which activates transcription from CRE-containing promoters, CREB-2 functions as a specific repressor of CRE-dependent transcription.