MEGF9 Antibody / Multiple epidermal growth factor-like domains protein 9

MEGF9 (Multiple EGF-like domains protein 9; also EGF-like protein 5) is a 63 kDa (predicted) novel transmembrane glycoprotein that shares some homology to beta -chains of laminin. It is expressed by hepatocytes, cerebellar Purkinje cells, Schwann cells, keratinocytes and intestinal epithelium. MEGF9 is suggested to participate in cell motility, and its absence correlates with tumor cell migration. Mature human MEGF9 is 572 amino acids (aa) in length. It is a single span type I transmembrane protein that contains a 484 aa extracellular region (aa 31-514) plus a 68 aa C-terminal cytoplasmic domain. The extracellular region possesses a lengthy Pro-rich region (aa 55-200), followed by five EGF-like domains (aa 204-451).