SPTN2 Rabbit Polyclonal Antibody

Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2)| is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to| but distinct from| the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia| SCA5| that is characterized by neurodegeneration| progressive locomotor incoordination| dysarthria| and uncoordinated eye movements.

The SPTN2 Rabbit Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of spectrin beta non-erythrocytic 2 (SPTN2) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human SPTN2 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards SPTN2 protein, making it an ideal tool for various applications such as western blotting, immunohistochemistry, and immunofluorescence.

The SPTN2 Rabbit Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested for its specificity and sensitivity. It is supplied as a purified IgG fraction, and is suitable for use in both research and diagnostic applications. This antibody is provided in a convenient format, with a concentration of 1 mg/mL, and can be stored at -20°C for long-term use.

Overall, the SPTN2 Rabbit Polyclonal Antibody is a reliable and effective tool for the detection and quantification of SPTN2 protein in various biological samples. Its high specificity and sensitivity make it an ideal choice for researchers and clinicians working in the fields of cell biology, neuroscience, and cancer research.