SREBP-1(Phospho Ser439) Polyclonal Antibody

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1)| which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage| the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor| and the mature nuclear form is rapidly catabolized| thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

The SREBP-1(Phospho Ser439) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of SREBP-1 protein phosphorylated at Serine 439. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the target protein.

SREBP-1, also known as Sterol Regulatory Element-Binding Protein 1, is a transcription factor that plays a crucial role in the regulation of lipid metabolism and cholesterol homeostasis. Phosphorylation of SREBP-1 at Serine 439 has been shown to modulate its activity and function, making it an important site for investigation in various cellular processes.

This polyclonal antibody is rigorously validated for its specificity and sensitivity through multiple experimental approaches, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits minimal cross-reactivity with other related proteins, ensuring accurate and reliable results.

The SREBP-1(Phospho Ser439) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, allowing for multiple experiments and applications. The antibody is suitable for use in various research areas, including lipid metabolism, cholesterol regulation, and cellular signaling pathways.

With its exceptional performance and reliability, the SREBP-1(Phospho Ser439) Polyclonal Antibody is an indispensable tool for researchers and scientists aiming to investigate the role and function of SREBP-1 phosphorylation in cellular processes.