Stat3(Phospho Ser727) Polyclonal Antibody

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors| STAT family members are phosphorylated by the receptor associated kinases| and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs| EGF| IL5| IL6| HGF| LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli| and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper

The Stat3(Phospho Ser727) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated Serine 727 residue on the Signal Transducer and Activator of Transcription 3 (Stat3) protein. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity towards the phosphorylated form of Stat3 at Ser727.

The phosphorylation of Stat3 at Ser727 plays a crucial role in the regulation of various cellular processes, including cell proliferation, differentiation, and survival. By targeting this specific phosphorylation site, the Stat3(Phospho Ser727) Polyclonal Antibody enables researchers to investigate the activation and signaling pathways of Stat3 in a wide range of biological samples.

This antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits excellent sensitivity and specificity, allowing for accurate and reliable detection of phosphorylated Stat3 at Ser727 in both cell lysates and tissue sections.

The Stat3(Phospho Ser727) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex antibody preparation procedures. It is compatible with a variety of experimental conditions and can be used in combination with other antibodies or detection reagents for multiplex analysis.

With its exceptional performance and versatility, the Stat3(Phospho Ser727) Polyclonal Antibody is an indispensable tool for researchers studying the intricate signaling pathways involving Stat3 phosphorylation. Its reliable and reproducible results make it an ideal choice for both basic research and clinical applications.