TANK Polyclonal Antibody

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The TRAF family member associated NFKB activator encoded by TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The TANK Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of TANK protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human TANK protein. The resulting polyclonal antibody exhibits high affinity and specificity towards TANK protein, making it an ideal tool for various applications such as Western blotting, immunoprecipitation, and immunohistochemistry.

The TANK Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested for its specificity and sensitivity. It recognizes a single band of the expected molecular weight in Western blot analysis, and shows minimal cross-reactivity with other proteins. The antibody is supplied as a purified IgG fraction, and is suitable for use in both research and diagnostic applications.

In summary, the TANK Polyclonal Antibody is a reliable and high-quality reagent that enables accurate detection and quantification of TANK protein in various biological samples. Its high specificity and sensitivity make it an essential tool for researchers and clinicians working in the fields of immunology, cancer biology, and signal transduction.