Tie2(Phospho-Tyr992) Rabbit Polyclonal Antibody

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains| three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described| but their full-length nature is not known.

The Tie2(Phospho-Tyr992) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of Tie2 protein phosphorylated at tyrosine 992. This antibody has been rigorously validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The Tie2 receptor, also known as angiopoietin-1 receptor, plays a crucial role in angiogenesis and vascular development. Phosphorylation of tyrosine 992 is a key event in the activation of Tie2 signaling pathway, which regulates endothelial cell survival, migration, and vascular permeability.

Our Tie2(Phospho-Tyr992) Rabbit Polyclonal Antibody has been carefully designed and manufactured to ensure high specificity and sensitivity. It has been extensively tested on various cell lines and tissues to guarantee reliable and reproducible results.

With its exceptional performance, this antibody is an indispensable tool for researchers studying angiogenesis, vascular biology, and related fields. Its versatility and reliability make it suitable for a wide range of experimental applications, enabling researchers to gain valuable insights into the molecular mechanisms underlying Tie2 signaling.

Order your Tie2(Phospho-Tyr992) Rabbit Polyclonal Antibody today and unlock the potential of your research.