TIRAP(Phospho Tyr86) Polyclonal Antibody

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

The TIRAP(PHOSPHO TYR86) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of TIRAP protein phosphorylated at tyrosine 86. This antibody is produced using advanced polyclonal antibody production techniques, ensuring high affinity and specificity towards the target protein.

The TIRAP protein plays a crucial role in the Toll-like receptor (TLR) signaling pathway, which is essential for the activation of the innate immune response. Phosphorylation of TIRAP at tyrosine 86 is known to regulate its function and downstream signaling events. Therefore, the TIRAP(PHOSPHO TYR86) Polyclonal Antibody serves as an invaluable tool for researchers studying the intricate mechanisms of TLR signaling and its implications in various physiological and pathological processes.

This antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of TIRAP phosphorylated at tyrosine 86 in complex biological samples.

The TIRAP(PHOSPHO TYR86) Polyclonal Antibody is supplied as a liquid formulation, ensuring ease of use and convenience. It is provided in a ready-to-use format, eliminating the need for time-consuming antibody preparation steps. The antibody is available in different sizes to accommodate various experimental requirements.

With its exceptional performance and reliability, the TIRAP(PHOSPHO TYR86) Polyclonal Antibody is an indispensable tool for researchers investigating TLR signaling pathways and their involvement in immune responses. Its high specificity and sensitivity make it an ideal choice for accurate and precise detection of TIRAP phosphorylated at tyrosine 86, facilitating groundbreaking discoveries in immunology and related fields.