UDP-GlcDH Polyclonal Antibody

The protein encoded by UGDH (UDP-glucose 6-dehydrogenase) converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of UGDH is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.

The UDP-GlcDH Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of UDP-glucose dehydrogenase (UDP-GlcDH) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human UDP-GlcDH protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for its specificity and sensitivity through various assays.

The UDP-GlcDH Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to detect UDP-GlcDH in a variety of tissues and cell lines, including liver, kidney, brain, and muscle. This antibody is also suitable for use in studies investigating the role of UDP-GlcDH in various biological processes, such as glycogen metabolism, glycosylation, and cell signaling.

The UDP-GlcDH Polyclonal Antibody is provided as a liquid solution in phosphate-buffered saline (PBS) containing 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different research applications. This antibody is a valuable tool for researchers studying UDP-GlcDH and its role in various biological processes.