USP11 Polyclonal Antibody

USP11 (Ubiquitin Specific Peptidase 11) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding. GO annotations related to this gene include cysteine-type endopeptidase activity and thiol-dependent ubiquitinyl hydrolase activity. An important paralog of this gene is USP4. rotease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed: 12084015, PubMed: 15314155, PubMed: 17897950, PubMed: 19874889, PubMed: 20233726, PubMed: 24724799). Inhibits the degradation of target proteins by the proteasome (PubMed: 12084015). Cleaves preferentially Lys-6 and Lys-63-linked ubiquitin chains. Has lower activity with Lys-11 and Lys-33-linked ubiquitin chains, and extremely low activity with Lys-27, Lys-29 and Lys-48-linked ubiquitin chains (in vitro) (PubMed: 24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed: 17897950, PubMed: 19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed: 15314155, PubMed: 20233726).

The USP11 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of USP11 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human USP11 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards USP11 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and immunofluorescence.

The USP11 Polyclonal Antibody is validated for use in human, mouse, and rat samples, and has been extensively tested for its specificity and sensitivity. This antibody recognizes a single band of approximately 150 kDa in Western blot analysis of various cell lysates, and shows minimal cross-reactivity with other proteins. Additionally, this antibody has been shown to be highly effective in detecting endogenous USP11 protein in various tissues, including brain, liver, and kidney.

The USP11 Polyclonal Antibody is supplied as a purified IgG fraction, and is available in various sizes to suit different experimental needs. This antibody is provided in a buffer containing 0.02% sodium azide as a preservative, and should be stored at -20°C for long-term storage. Overall, the USP11 Polyclonal Antibody is a reliable and high-quality tool for the detection of USP11 protein in various biological samples, and is an essential reagent for researchers studying the role of USP11 in various cellular processes.