Wilms Tumor 1 Protein (WT1)

Wilm’s Tumor (WT1), is a gene involved in the induction of Wilm’s Tumor, a sporadic and familial pediatric kidney tumor. Wilm’stumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenitalsystem. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm’s tumor and mesothelioma. WT1 has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor.