YB-1 Polyclonal Antibody

YBX1 encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. YBX1 may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of YBX1 are found on multiple chromosomes.

The YB-1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Y-box binding protein 1 (YB-1) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human YB-1 protein, followed by affinity purification using a YB-1 peptide column. The YB-1 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both the phosphorylated and non-phosphorylated forms of YB-1 protein and has been shown to cross-react with YB-1 from various species, including human, mouse, and rat. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is suitable for use in research and diagnostic applications related to cancer, inflammation, and stress response pathways. The YB-1 Polyclonal Antibody is a reliable and valuable tool for investigating the role of YB-1 in various biological processes and diseases.