• OAT Polyclonal Antibody
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YP-Ab-00711-100UL

OAT Polyclonal Antibody

OAT Polyclonal Antibody

Size
  • Gene Name: OAT
  • Immunogen: Synthesized peptide derived from OAT . at AA range: 100-180
  • Specificity: OAT Polyclonal Antibody detects endogenous levels of OAT protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: OAT; Ornithine aminotransferase; mitochondrial; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase
  • Background: ornithine aminotransferase(OAT) Homo sapiens This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010],
  • Function: catalytic activity:L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.,cofactor:Pyridoxal phosphate.,disease:Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA) [MIM:258870]. HOGA is a slowly progressive blinding autosomal recessive disorder.,pathway:Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.,similarity:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homotetramer.,
  • Species: Human;Mouse;Rat
  • Range: WB;ELISA
  • Protein: Ornithine aminotransferase mitochondrial
  • DA: 48kD
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