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Upingbio
SKU(재고 관리 코드):YP-Ab-00912-100UL
EKLF (Acetyl Lys274) rabbit pAb
EKLF (Acetyl Lys274) rabbit pAb
- Gene Name: KLF1 EKLF
- Immunogen: Synthesized peptide derived from human EKLF (Acetyl Lys274)
- Specificity: This antibody detects endogenous levels of Human EKLF (Acetyl Lys274)
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:1000-2000 ELISA 1:5000-20000
- Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: Krueppel-like factor 1 (Erythroid krueppel-like transcription factor;EKLF)
- Background: This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009],
- Function: function:Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. When sumoylation, acts as a Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor, by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.,PTM:Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity.,PTM:Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity.,PTM:Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex.,simila
- Species: Human;Rat;Mouse;
- Range: WB; ELISA
- Protein: EKLF (Acetyl Lys274)
- DA: 40kD
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