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Upingbio
SKU(재고 관리 코드):YP-Ab-03825-100UL
Dok-6 Polyclonal Antibody
Dok-6 Polyclonal Antibody
- Gene Name: DOK6
- Immunogen: The antiserum was produced against synthesized peptide derived from human DOK6. AA range:111-160
- Specificity: Dok-6 Polyclonal Antibody detects endogenous levels of Dok-6 protein.
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: DOK6; DOK5L; Docking protein 6; Downstream of tyrosine kinase 6
- Background: docking protein 6(DOK6) Homo sapiens DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008],
- Function: domain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.,PTM:On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.,similarity:Belongs to the DOK family. Type B subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:Interacts via its PTB domain with phosphorylated RET.,tissue specificity:Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.,
- Species: Human;Mouse
- Range: WB;IHC;IF;ELISA
- Protein: Docking protein 6
- DA: 43kD
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