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Upingbio
SKU(재고 관리 코드):YP-Ab-04122-100UL
RGS14 Polyclonal Antibody
RGS14 Polyclonal Antibody
- Gene Name: RGS14
- Immunogen: The antiserum was produced against synthesized peptide derived from human RGS14. AA range:125-174
- Specificity: RGS14 Polyclonal Antibody detects endogenous levels of RGS14 protein.
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: RGS14; Regulator of G-protein signaling 14; RGS14
- Background: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],
- Function: function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.,similarity:Contains 1 GoLoco domain.,similarity:Contains 1 RGS domain.,similarity:Contains 2 RBD (Ras-binding) domains.,
- Species: Human;Mouse;Rat
- Range: WB;ELISA;IHC
- Protein: Regulator of G-protein signaling 14
- DA: 65kD
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