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Upingbio
SKU(재고 관리 코드):YP-Ab-04484-100UL
BRAP mouse mAb
BRAP mouse mAb
- Reaction species: Human
- Gene Name: brap
- Molecular weight (DA): 67kD
- Immunogen: Purified recombinant human BRAP protein fragments expressed in E.coli.
- Specificity: This antibody detects endogenous levels of BRAP and does not cross-react with related proteins.
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Monoclonal, Mouse
- Dilution ratio: wb dilution 1:1000
- Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
- Concentration: mg/ml
- Storage: -20°C/1 year
- Other Names: 3010002G07Rik;BRAP2;BRCA1 associated protein;EC 6.3.2.;Galectin 2 binding protein;IMP; Impedes mitogenic signal propagation;Renal carcinoma antigen NY REN 63; RING finger protein 52;RNF52;zgc:92894.
- Background: The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008],
- Function: function:Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 UBP-type zinc finger.,subunit:Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal portion of BCRA1 interacts with DDB1.,tissue specificity:Expressed in breast epithelial cell lines.,
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