• MDFIC Polyclonal Antibody
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YP-Ab-05769-100UL

MDFIC Polyclonal Antibody

MDFIC Polyclonal Antibody

Size
  • Gene Name: MDFIC
  • Immunogen: Synthesized peptide derived from human protein . at AA range: 100-180
  • Specificity: MDFIC Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
  • Function: domain:The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm.,function:Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.,similarity:Belongs to the MDFI family.,subcellular location:Isoform 1 localizes to the nucleolus and also shows a granular distribution in the cytoplasm. Isoform 2 is predominantly distributed throughout the cytoplasm, with only weak expression in the nucleus.,
  • Species: Human;Mouse
  • Range: WB;ELISA
  • Protein: MyoD family inhibitor domain-containing protein (I-mfa domain-containing protein) (hIC)
  • DA: 27kD
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