• PAPP2 Polyclonal Antibody
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YP-Ab-06917-100UL

PAPP2 Polyclonal Antibody

PAPP2 Polyclonal Antibody

Size
  • Gene Name: PAPPA2 PLAC3
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: PAPP2 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010],
  • Function: catalytic activity:Cleavage of the 143-Ser-|-Lys-144 bond in insulin-like growth factor binding protein (IGFBP)-5.,cofactor:Binds 1 zinc ion per subunit.,function:Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.,similarity:Belongs to the peptidase M43B family.,similarity:Contains 5 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Expressed abundantly in placenta, and non-pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.,
  • Species: Human;Rat;Mouse;
  • Range: WB;ELISA
  • Protein: Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E)
  • DA: 197kD
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