• TP4A1 Polyclonal Antibody
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YP-Ab-06967-100UL

TP4A1 Polyclonal Antibody

TP4A1 Polyclonal Antibody

Size
  • Gene Name: PTP4A1 PRL1 PTPCAAX1
  • Immunogen: Synthesized peptide derived from part region of human protein
  • Specificity: TP4A1 Polyclonal Antibody detects endogenous levels of protein.
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: protein tyrosine phosphatase type IVA, member 1(PTP4A1) Homo sapiens This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013],
  • Function: catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed in fetal liver.,enzyme regulation:Inhibited by sodium orthovanadate and pentamidine.,function:Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.,induction:Strongly down-regulated upon tetrodotoxin treatment.,PTM:Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subcellular location:And mitotic spindle.,subunit:Homotrimer. Interacts with ATF5 (By similarity). Inte
  • Species: Human;Mouse;Rat
  • Range: WB;ELISA
  • Protein: Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)
  • DA: 19kD
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