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Upingbio
SKU(재고 관리 코드):YP-Ab-07756-100UL
PODO Polyclonal Antibody
PODO Polyclonal Antibody
- Gene Name: NPHS2
- Immunogen: Synthesized peptide derived from part region of human protein
- Specificity: PODO Polyclonal Antibody detects endogenous levels of protein.
- Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000 ELISA 1:5000-20000
- Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Background: This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
- Function: disease:Defects in NPHS2 are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN) [MIM:600995]. SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. Focal segmental glomerulosclerosis is present at later stages.,function:Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.,similarity:Belongs to the band 7/mec-2 family.,subunit:Interacts with nephrin/NPHS1 and KIRREL. Interacts directly with CD2AP. Interacts with DDN.,tissue specificity:Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli.,
- Species: Human;Rat;Mouse;
- Range: WB;ELISA
- Protein: Podocin
- DA: 42kD
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