• DGCR8 rabbit pAb
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YP-Ab-08233-100UL

DGCR8 rabbit pAb

DGCR8 rabbit pAb

Size
  • Gene Name: DGCR8 C22orf12 DGCRK6 LP4941
  • Immunogen: Synthesized peptide derived from human DGCR8 AA range: 467-517
  • Specificity: This antibody detects endogenous levels of DGCR8 at Human/Mouse
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.348% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Microprocessor complex subunit DGCR8 (DiGeorge syndrome critical region 8)
  • Background: This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
  • Function: disease:May play a part in the etiology of the velocardiofacial/DiGeorge syndrome (VCFS/DGS), a developmental disorder characterized by structural and functional palate anomalies, conotruncal cardiac malformations, immunodeficiency, hypocalcemia, and typical facial anomalies. Most cases result from a deletion of chromosome 22q11.2 (the DiGeorge syndrome chromosome region, or DGCR).,similarity:Contains 1 WW domain.,similarity:Contains 2 DRBM (double-stranded RNA-binding) domains.,tissue specificity:Ubiquitously expressed.,
  • Species: Human; Mouse
  • Range: WB
  • Protein: DGCR8
  • DA: 85kD
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