• LYRM4 rabbit pAb
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YP-Ab-08460-100UL

LYRM4 rabbit pAb

LYRM4 rabbit pAb

Size
  • Gene Name: LYRM4 C6orf149 ISD11 CGI-203
  • Immunogen: Synthesized peptide derived from human LYRM4 AA range: 30-80
  • Specificity: This antibody detects endogenous levels of LYRM4 at Human/Mouse
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC-p 1：50-200. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Background: The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016],
  • Function: function:May be involved in mitochondrial iron-sulfur protein biosynthesis.,miscellaneous:Reduction of LYRM4 levels by siRNA increases the total iron content, and reduces cytosolic and mitochondrial aconitase activities and NFS1 protein levels.,pathway:Cofactor biosynthesis; iron-sulfur cluster biosynthesis.,similarity:Belongs to the complex I LYR family.,subunit:Interacts with FXN. Interaction is increased by nickel. Interaction is inhibited by calcium, magnesium, manganese, copper, cobalt, zinc, and iron. Forms a complex with the cytosolic/nuclear form of NFS1. The complex increased the stability of NFS1.,tissue specificity:Reduced mRNA levels in Friedreich ataxia (FA) patients.,
  • Species: Human; Mouse
  • Range: IHC;IF
  • Protein: LYRM4
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