• SREBP-2 (Phospho-Ser455) rabbit pAb
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YP-Ab-10498-100UL

SREBP-2 (Phospho-Ser455) rabbit pAb

SREBP-2 (Phospho-Ser455) rabbit pAb

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  • Gene Name: SREBF2 BHLHD2 SREBP2
  • Immunogen: Synthesized peptide derived from human SREBP-2 (Phospho-Ser455)
  • Specificity: This antibody detects endogenous levels of SREBP-2 (Phospho-Ser455) at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.154% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2]
  • Background: This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
  • Function: function:Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.,PTM:At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.,similarity:Belongs to the SREBP family.,similarity:Contains 1 basic
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: SREBP-2 (Phospho-Ser455)
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