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Upingbio
SKU(재고 관리 코드):YP-Ab-10515-100UL
XRCC1 (Phospho-Thr284) rabbit pAb
XRCC1 (Phospho-Thr284) rabbit pAb
- Gene Name: XRCC1
- Immunogen: Synthesized peptide derived from human XRCC1 (Phospho-Thr284)
- Specificity: This antibody detects endogenous levels of XRCC1 (Phospho-Thr284) at Human, Mouse,Rat
- Composition: Liquid in PBS containing 50% glycerol, and 0.171% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000
- Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
- Background: The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],
- Function: function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,
- Species: Human; Mouse;Rat
- Range: WB
- Protein: XRCC1 (Phospho-Thr284)
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