• Shc3 (Phospho-Tyr424) rabbit pAb
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YP-Ab-10542-100UL

Shc3 (Phospho-Tyr424) rabbit pAb

Shc3 (Phospho-Tyr424) rabbit pAb

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  • Gene Name: SHC3 NSHC SHCC
  • Immunogen: Synthesized peptide derived from human Shc3 (Phospho-Tyr424)
  • Specificity: This antibody detects endogenous levels of Shc3 (Phospho-Tyr424) at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.198% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
  • Function: function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.,tissue specificity:Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord.,
  • Species: Human; Mouse;Rat
  • Range: WB
  • Protein: Shc3 (Phospho-Tyr424)
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