• WIPI1 Polyclonal Antibody
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YP-Ab-10590-100UL

WIPI1 Polyclonal Antibody

WIPI1 Polyclonal Antibody

Size
  • Gene Name: WIPI1 WIPI49
  • Immunogen: Synthetic Peptide of WIPI1
  • Specificity: WIPI1 Polyclonal Antibody detects endogenous levels of WIPI1
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000, ELISA 1:10000-20000
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: WD repeat domain, phosphoinositide interacting 1
  • Background: WD repeat domain, phosphoinositide interacting 1(WIPI1) Homo sapiens This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
  • Function: function:May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.,similarity:Contains 3 WD repeats.,subcellular location:Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles.,subunit:Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes.,tissue specificity:Ubiquitously expressed. Highly expressed in skeletal muscle, heart, testis, pancreas and placenta. Highly expressed in G361, Sk-mel-28, Sk-mel-13, WM852 and WM451 cells. Up-regulated in a variety of tumor tissues.,
  • Species: Human(mouse94%)
  • Range: WB;ELISA
  • Protein: WIPI1
  • DA: 48kD
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