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Upingbio
SKU(재고 관리 코드):YP-Ab-12257-100UL
CXXC4 rabbit pAb
CXXC4 rabbit pAb
- Gene Name: CXXC4 IDAX
- Immunogen: Synthesized peptide derived from human CXXC4 AA range: 15-65
- Specificity: This antibody detects endogenous levels of CXXC4 at Human/Mouse/Rat
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1：500-2000
- Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Background: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
- Function: function:Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.,similarity:Contains 1 CXXC-type zinc finger.,subunit:Interacts with the PDZ domain of DVL1.,
- Species: Human; Mouse;Rat
- Range: WB
- Protein: CXXC4
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