• GSDMD N-terminal rabbit pAb
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YP-Ab-12523-100UL

GSDMD N-terminal rabbit pAb

GSDMD N-terminal rabbit pAb

Size
  • Gene Name: GSDMD
  • Immunogen: Synthesized peptide derived from human GSDMD. AA range:1-100
  • Specificity: The antibody detects endogenous full lenth and n-ternal fragment of gsdmd protein,
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IF: 1:50-200 WB: 1:1000-3000 IHC: 1:50-300
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Function: Cleavage at Asp-275 by CASP1 (mature and uncleaved precursor forms), CASP4, CASP5 or CASP8 relieves autoinhibition and is sufficient to initiate pyroptosis (PubMed:26375003, PubMed:29898893, PubMed:32109412). Cleavage by CASP1 and CASP4 is not strictly dependent on the consensus cleavage site on GSDMD but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part (PubMed:32109412). Cleavage by CASP8 takes place following inactivation of MAP3K7/TAK1 by Yersinia toxin YopJ (By similarity). Cleavage at Asp-87 by CASP3 or CAPS7 inactivates the ability to mediate pyroptosis (PubMed:28392147, PubMed:28045099).
  • Species: Human;Mouse;Rat
  • Range: IF;WB;IHC
  • Protein: Gasdermin domain-containing protein 1,Gasdermin-D,GSDMD,GSDMD-CT,GSDMD-NT,GSDMD_HUMAN
  • DA: 36 55kD
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