• Duffy Polyclonal Antibody
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YP-Ab-13200-100UL

Duffy Polyclonal Antibody

Duffy Polyclonal Antibody

Size
  • Gene Name: DARC
  • Immunogen: The antiserum was produced against synthesized peptide derived from human DARC. AA range:1-50
  • Specificity: Duffy Polyclonal Antibody detects endogenous levels of Duffy protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: DARC; FY; GPD; Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD antigen CD234
  • Background: The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
  • Function: disease:Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to vivax malaria. This allele is found predominantly in population of African origin.,function:Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi.,online information:Blood group antigen gene mutation database,online information:Duffy antigen entry,polymorphism:DARC is responsible for the Duffy blood group system. The molecular basis of the Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and Asp-42 to Fy(B).,polymorphism:Genetic variation in DARC is associated with white blood cell count quantitative trait locus type 1 (WBCQ1) [MIM:611862]. Peripheral white blood cell count (WBC) is a common clinical measurement, us
  • Species: Human;Rat;Mouse;
  • Range: IF;ELISA
  • Protein: Duffy antigen/chemokine receptor
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