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Upingbio
SKU(재고 관리 코드):YP-Ab-14582-100UL
CaMK2 (Phospho-Thr286) Antibody
CaMK2 (Phospho-Thr286) Antibody
- Gene Name: CAMK2D CAMKD
- Immunogen: Synthesized pospho peptide derived from human CaMK2 (Phospho-Thr286)
- Specificity: This antibody detects endogenous pospho levels of human CaMK2 (Phospho-Thr286)
- Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source: Polyclonal, Rabbit,IgG
- Dilution ratio: WB 1:500-2000, ELISA(peptide)1:5000-20000
- Purification process: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Concentration: 1 mg/ml
- Storage: -20°C/1 year
- Other Names: Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta;CaMK-II subunit delta;EC 2.7.11.17)
- Background: The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008],
- Function: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Postsynaptic lipid rafts.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric
- Species: Human; Mouse; Rat
- Range: WB; ELISA
- Protein: CaMK2 (Phospho-Thr286)
- DA: 54kD
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