• MEK Kinase-6 Polyclonal Antibody
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YP-Ab-14834-100UL

MEK Kinase-6 Polyclonal Antibody

MEK Kinase-6 Polyclonal Antibody

Size
  • Gene Name: MAP3K6
  • Immunogen: The antiserum was produced against synthesized peptide derived from human MAP3K6. AA range:281-330
  • Specificity: MEK Kinase-6 Polyclonal Antibody detects endogenous levels of MEK Kinase-6 protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: MAP3K6; ASK2; MAPKKK6; MEKK6; Mitogen-activated protein kinase kinase kinase 6; Apoptosis signal-regulating kinase 2
  • Background: This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
  • Function: catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.,function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
  • Species: Human;Mouse
  • Range: IHC;IF;ELISA
  • Protein: Mitogen-activated protein kinase kinase kinase 6
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