• MLKL Polyclonal Antibody
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YP-Ab-14857-100UL

MLKL Polyclonal Antibody

MLKL Polyclonal Antibody

Size
  • Gene Name: MLKL
  • Immunogen: Synthesized peptide derived from MLKL . at AA range: 40-120
  • Specificity: MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.
  • Composition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • Source: Polyclonal, Rabbit,IgG
  • Dilution ratio: WB 1:500-2000;IHC-p 1:50-300
  • Purification process: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: MLKL; Mixed lineage kinase domain-like protein
  • Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
  • Function: domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
  • Species: Human;Rat;Mouse;
  • Range: WB;IHC
  • Protein: Mixed lineage kinase domain-like protein
  • DA: 55kD
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