• BRCA1 (Phospho Ser1497) Rabbit pAb
1 1

Upingbio

YP-Ab-17142-100UL

BRCA1 (Phospho Ser1497) Rabbit pAb

BRCA1 (Phospho Ser1497) Rabbit pAb

Size
  • Gene Name: BRCA1 RNF53
  • Immunogen: Synthesized peptide derived from human BRCA1 (Phospho Ser1497)
  • Specificity: This antibody detects endogenous levels of BRCA1 (Phospho Ser1497) Rabbit pAb at Human, Mouse,Rat
  • Composition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • Source: Rabbit,polyclonal
  • Dilution ratio: WB 1:500-2000 IHC 1:50-200
  • Purification process: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • Concentration: 1 mg/ml
  • Storage: -20°C/1 year
  • Other Names: Breast cancer type 1 susceptibility protein (EC 6.3.2.-) (RING finger protein 53)
  • Background: BRCA1, DNA repair associated(BRCA1) Homo sapiens This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript varian
  • Function: disease:Defects in BRCA1 are a cause of genetic susceptibility to breast cancer (BC) [MIM:113705, 114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early-onset breast cancer. Mutations in BRCA1 are thought to be responsible for 45% of inherited breast cancer. Moreover, BRCA1 carriers have a 4-fold increased risk of colon cancer, whereas male carriers face a 3-fold increased risk of prostate cancer. Cells lacking BRCA1 show defects in DNA repair by homologous recombination.,disease:Defects in BRCA1 are a cause of genetic susceptibility to ovarian cancer [MIM:113705].,disease:Defects in BRCA1 are a cause of susceptibility to familial breast-ovarian cancer type 1 (BROVCA1) [MIM:604370]. Mutations in BRCA1 are
  • Species: Human, Mouse,Rat
  • Range: IHC,WB
  • Protein: Breast cancer type 1 susceptibility protein (EC 6.3.2.-) (RING finger protein 53)
전체 세부 정보 보기